Major Histocompatibility Complex Class II Prediction
نویسندگان
چکیده
منابع مشابه
Major histocompatibility complex class II and BTNL2 associations in sarcoidosis.
Infect Dis 2009; 9: 162–172. 4 Li T, Chiang JY. Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4a and coactivators, and suppression of small heterodimer partner gene expression. Drug Metab Dispos 2006; 34: 756–764. 5 Handschin C, Meyer UA. Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. Arch Biochem ...
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We describe here a new method for predicting class II major histocompatibility complex-binding peptides, based on the preferences observed in a systematic series of peptide binding experiments where each position in a "minimal" peptide was replaced individually by every amino acid. The DRB1*0401 peptide binding preferences were determined and incorporated into a computer program that looks thro...
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Description The genes of the Human Leukocyte Antigen (HLA) system reside on chromosome 6, and code for cellsurface proteins that play a crucial role in the presentation of endogenic peptides to effector cells of the immune system. The HLA Class I protein molecule is a heterodimer, made up of two chains; a heavy one and a light one (beta 2 microglobulin). The HLA-B gene is one of the three HLA C...
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Major histocompatibility complex (MHC)-I and MHC-II molecules play an essential role in the immune response to pathogens by virtue of their ability to present peptides to CD8⁺ and CD4⁺ T cells, respectively. Given this critical role, MHC-I and MHC-II genes are regulated in a tight fashion at the transcriptional level by a variety of transcription factors that interact with conserved cis-acting ...
متن کاملPrimitive synteny of vertebrate major histocompatibility complex class I and class II genes.
Major histocompatibility complex (MHC) class I and class II molecules bind to and display peptidic antigens acquired from pathogens that are recognized by lymphocytes coordinating and executing adaptive immune responses. The two classes of MHC proteins have nearly identical tertiary structures and were derived from a common ancestor that probably existed not long before the emergence of the car...
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ژورنال
عنوان ژورنال: American Journal of Bioinformatics Research
سال: 2012
ISSN: 2167-6992
DOI: 10.5923/j.bioinformatics.20120201.03